Clinical Efficacy and Safety of an Anti-Acne Cosmetics Containing Natural Salicylic Acid and an Epidermal Penetrating Peptide
The purpose of this study is to investigate clinical efficacy and safety on anti-acne cosmetics containing 0.5% natural salicylic acid and 0.01% transdermal penetrating arginine peptide (R6). In the case of non-inflammatory lesions, the results showed that the lesions improved from 19.08 ± 35.46 after 2 weeks to 40.00 ± 32.33 after 4 weeks and to 43.31 ± 28.49 after 6 weeks. Statistically, non-inflammatory lesions decreased statistically after 4 weeks and after 6 weeks except for 2 weeks of use compared to before using acne cream (p<0.02). For inflammatory lesions, the results represented that the total lesions improved from 19.08 ± 35.46 after 2 weeks to 40.00 ± 32.33 after 4 weeks and to 43.31 ± 28.49 after 6 weeks. For inflammatory lesions, the inflammatory variable decreased statistically, both after 2 weeks of use, 4 weeks after use and 6 weeks after use (p<0.005). For total lesions (non-inflammatory lesions + inflammatory lesions), The results showed that the total lesions improved from 28.96 ± 24.25 after 2 weeks to 43.68 ± 17.97 after 4 weeks and to 51.41 ± 18.19 after 6 weeks. For total lesions, the total lesions decreased statistically, both after two weeks of use, four weeks after use and six weeks after use (p<0.001). No specific skin adverse events were observed in all subjects participating that participated in the present study. Therefore, the test product containing a natural salicylic acid and a skin penetrating peptide is have beneficial effects in reducing acne for 6 weeks.