Spectrophotometric Determination of Antiulcer drugs using 2,2’-bipyridine as Complexing agent

Abstract

Simple, sensitive and rapid   spectrophotometric method for the determination of certain proton pump inhibitors belonging to the benzimidazole class of compounds has been developed. The method is based on the reaction of these antiulcer drugs namely omeprazole (OMZ), lansoprazole (LNZ), pantoprazole (PNZ), rabeprazole (RBZ) and esomeprazole (EMZ) with iron (III) and subsequent complexation with 2,2’ -bipyridine which forms a pink coloured product with maximum absorption at 530 nm. The commonly encountered excipients and additives along with the drug did not interfere with the determination. Antiulcer drugs in the range of 200 - 4000 ng mL^-1 for LNZ, PNZ and RBZ, 80 - 2800 ng mL^-1 for OMZ and 200 - 3800 ng mL^-1 for EMZ can be determined by this method. Results of the analysis of commercial capsules/tablets (omelac capsule, lanpro capsule, pan tablet, rabeloc tablet and raciper tablet for OMZ, LNZ, PNZ, RBZ and EMZ, respectively) by this procedure agree well with those of the reported method.