The Association Of G>C -765 Promoter Polymorphism Of Cox-2 Gene With Colorectal Cancer: A Case Study In Dr. Moh. Hoesin General Hospital, Palembang, Indonesia

Abstract

Colorectal cancer (CRC) is a common malignancy in the gastrointestinal tract which ranks fourth among all cancers worldwide. Polymorphism is a mutation in a gene in a population with a frequency greater than 1%. The impact of this polymorphism is a change in the vulnerability of a population towards a disease.To analyse the relationship between G>C polymorphism in promoter -765 of COX 2 gene and the risk of contracting colorectal cancer in Asian population living in Palembang, South Sumatera Indonesia.Analytical observational study with a comparative study approach (case control) to obtain associationship of known allele polymorphism of COX-2 gene variant at Promoter -765 G > C with incidences of CRC cases. The association was analysed using chi-square test and fisher's exact test between the genotype mutant type (CC and GC) compared to normal wild-type genotype (GG) in both case and control groups. By using the wild type GG genotype as a comparison, the statistical results showed no significant difference in the proportion of colorectal cancer cases in homozygous CC mutants and wildtype GG genotype with the p value of 0.1145. The similar finding was also found in heteroxygous mutant GC genotype where there was no significant correlation of the gene variant with the incidence of colorectal cancer found in this study (p = 1.00).

Genotype polymorphism (CC and GC) at-765 promoter of COX-2 gene was not significantly associated with the incidence of colorectal cancer in population living in Palembang, Indonesia.