Poly Ethylene Glycol/Chitosan/Iodine Bio-Composites and Their Applications

Abstract

Films were manufacturedfrom poly ethylene glycol /chitosan polymeric matrix with the addition of Iodine for treating wounds infected with the disease, especially diabetes. Iodine element was added with different weight percents (6,8 and 10). As a solution and film states are used to investigate is healing action. Evaluating the healing action is done by applied these solution and films to the injured rat's and the celavix treatment was used for comparing. The antibacterial activity was checked by expose the prepared samples to the action of Escherichia coli (gram negative) and Staphylococcus aureus (gram positive) microorganisms. Agar well diffusion method was used to evaluate the antibacterial action by measuring the inhibition zone diameter.Results showed that I2have the antibacterial ability against both Escherichia coli and Staphylococcus aureus microorganisms and this ability increased with increased I2 content in both films and solutions states. Complete healing obtains within seven days. UV and FTIR results proved presence of physical interaction between PEG-chitosan and iodine and the UV parameter will change with I2 content. Density, wettability, the color degree increased with iodine content.Surface morphologies of the prepared films, it can be concluded the Iodine ability to change the surface topography due to its ability to diffuse among the chains and fill its voids. This conclusion enhanced also by many changes occurred in the roughness parameters,(such as average surface roughness (Sa), core roughness depth (Sk), core fluid retention (Sci) and surface bearing index (sbi)), FESEM image, AFM 3D images, optical microscope images and contacts angles values.From the thermal transition view point, chitosan-PEG blend show miscible blend with single Tg and Iodine acts as plasticizer agent through reduction of Tg from (60.2 to 58.9 ºC).