Surface Modification of Catheter Tubes Based on Silicon Rubber and Coating by Chitosan for Anti-Bacterial Properties

Abstract

The catheter tubes made of silicone rubber are one of the most medical tools used in the medical field and in surgical catheter operations, which are exposed to the growth of the bacterial membrane during implantation in the human body, which causes a lot of infections and health problems. In this study, chitosan will use to improve the properties of the biological catheter tubes. The surface of the silicone rubber is coated with solution chitosan and bonded together by a bridge of a (3-aminopropyl) triethoxysilane (APTES).Silicone rubber surface characterized by FTIR, contact angle and SEM. Performing biologic tests of chitosan liquid before coating to determine the percentage of its effectiveness against Staphylococcus aureus (G+ve bacteria) and Escherichia coli (G-vebacteria)  bacteria by Agar Well Diffusion method, and conducting Biofilm Formation Assay. Best inhabitation rustle of chitosan by Agar Well Diffusion method was at 3% concentration of chitosan, therefor it was used for coating. The contact angle was decreased from 103.563? to 84.566? and the rustle of  Biofilm Formation Assay test showed that the chitosan inhibit the adhesion and prevents the formation of Biofilm for both types of bacteria strongly.