Insilico Studies on Protein Modified Graphene Oxide Sheets for Potential Biosensing Applications for Curcumin Metabolites

Authors

  • Nibedita Dey
  • Hritik Sharma

Abstract

Biosensors are gaining momentum in the field of life science research. Knowing the concentration of the drugs we consume in the form of nutraceuticals, medications, etc is essential for overall well-being of an individual. Curcumin is termed to one of the top selling supplements in the world. But this marvel compound transforms into various metabolites in the systemic circulation.  These metabolites hinder the therapeutic activity of curcumin. So, knowing the concentration of metabolites formed in each individual after a particular dosage of curcumin can help monitor the efficacy of this wonder drug. Avidin is a very cost effective and stable protein that has been used in combination with biotin in various bioassays and sensors. But, Avidin as a sole functional compound on graphene oxide has never been attempted before. Hence, before actual experimentation, docking studies were performed to prove the feasibility of the experiment in real time. The current study was performed between avidin and two major metabolites of curcumin i.e. curcuminglucuronide and curcumin sulphate.

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Published

2020-02-04

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Articles