Novel Tumour Suppressor Genes Associated With Oral Cancer

Authors

  • Ms.Madhumithaa Sivarajan, Dr. Vijayashree, Dr.Devaraj Ezhilarasan

Abstract

The cancer of oral cavity is the most prevalent with a recorded incidence
rate higher in male than in females. In India, oral and nasopharyngeal
carcinomas comprise upto half of all malignancies. The influence of
carcinogens and region specific epidemiological factors like tobacco, betel
leaf and quid chiming, makes it more aggressive and resistant to treatment.
Tumour suppressor genes (TSG's) are genes that prevent cells from
acquiring malignant characteristics. The aim of this study is to give a brief
review on the novel tumour suppressor genes implicated in oral cancer in
the last decade. A review with recent information about tumour suppressor
genes in oral cancer and its role from various search engines like medline,
google scholar, BiORXIV, medRXIV, Chem RXIV, MESH, cochrane etc.
Novel genes and signalling pathways have been implicated in the process
of tumorigenesis in the last few years. The reports and studies discussed in
this review helps in gaining knowledge about the role of tumor suppressor
genes in oral cancer. A most comprehensive knowledge on the pathways
will enable us to choose candidate genes as targets of therapy.

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Published

2019-12-31

Issue

Section

Articles